Author

Mark Ormiston

University of Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ataman SendoeliD· 3 shared Clara DuréiD· 3 shared David TaborskyiD· 3 shared Fabiola Valdivia-FranciaiD· 3 shared Homare YamahachiiD· 3 shared Katie HyamsiD· 3 shared Merve YiğitiD· 3 shared Peter F. RenziD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Ataman SendoelORCID

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Author profile →

3 papers

Recent·Most cited

In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging

Clara Duré, Umesh Ghoshdastider, Ramona Weber, Ameya Khandekar, Fabiola Valdivia-Francia, Peter F. Renz, Federica Sella, Katie Hyams, David Taborsky, Merve Yiğit, Mark Ormiston, Homare Yamahachi, Mitchell Paul Levesque, Stephanie J. Ellis, Ataman Sendoel

The paper uses in vivo single-cell ribosome profiling to study translational changes in mouse epidermal stem cells during aging, finding cell-type-specific translational reprogramming in aged stem cells.

Molecular Cell · May 22, 2026Peer-reviewedGenomics

The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control

Merve Yiğit, Ramona Weber, Umesh Ghoshdastider, Anupam Das, Kivanc Nesanir, Fabiola Valdivia-Francia, Katie Hyams, David Taborsky, Peter F. Renz, Mark Ormiston, Clara Duré, Homare Yamahachi, Marko Jovanović, Ataman Sendoel

This study identifies eIF2A's role in ribosome-associated quality control by showing it antagonizes USP10-dependent 40S subunit rescue, affecting turnover under stress.

bioRxiv · May 22, 2025 · PreprintMolecular Biology

In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component

Fabiola Valdivia-Francia, Umesh Ghoshdastider, Peter F. Renz, Daniel Spies, Mark Ormiston, Katie Hyams, Chenke Shi, Clara Duré, Merve Yiğit, David Taborsky, Ameya Khandekar, Ramona Weber, Homare Yamahachi, Stephanie J. Ellis, Ataman Sendoel

The paper uses in vivo single-cell CRISPR screening in mouse epidermis to identify a microprotein critical for ribosome function and cell proliferation.

bioRxiv · Mar 17, 2025 · PreprintGenetics