Katie Hyams

The paper uses in vivo single-cell ribosome profiling to study translational changes in mouse epidermal stem cells during aging, finding cell-type-specific translational reprogramming in aged stem cells.

This study identifies mRNA deadenylation as a key mechanism regulating body plan formation in mouse gastruloids by affecting mesoderm and endoderm differentiation.

This study identifies eIF2A's role in ribosome-associated quality control by showing it antagonizes USP10-dependent 40S subunit rescue, affecting turnover under stress.

The paper uses in vivo single-cell CRISPR screening in mouse epidermis to identify a microprotein critical for ribosome function and cell proliferation.

This study uses in vivo single-cell CRISPR to identify distinct TNF-α programs in clonal expansion and tumorigenesis, showing their roles in epithelial transformation and tumor initiation.