BiophysicsbioRxivPreprint
Buprenorphine Restricts the Conformational Landscape of the μ-Opioid Receptor
Simone Aureli, Maria Bzówka, Nicola Piasentin…·Francesco Luigi Gervasio
This study uses simulations to show that buprenorphine restricts the conformational states of the μ-opioid receptor compared to endomorphin-1, affecting signaling bias and efficacy.
DOI 10.64898/2026.06.12.731880