Cell BiologybioRxivPreprint
Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling
Joyce C. M. Meiring, Varsha Mahapatra, Molly S. C. Gravett…·Anna S. Akhmanova
This study shows taxanes induce conformational changes in microtubules, releasing GEF-H1 and activating RhoA signaling, leading to actin remodeling.
DOI 10.64898/2025.12.20.695343