NeuroscienceNeurobiology of DiseasePeer-reviewed
Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
Nicole Kreiter, Arun Pal, Xenia Lojewski…·Andreas Hermann
This study shows that TDP43 mutations cause motor neuron degeneration in ALS through mechanisms unrelated to TDP43 aggregation or mislocalization.
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