Meng Li

Spatial Transcriptomics Reveal Developmental Dynamics of the Human Cerebral Cortex and Striatum

This study uses spatial transcriptomics and snRNA-seq to identify 25 forebrain regions and characterize dynamic changes in the human fetal cortex and striatum during late first and early second trimesters.

A comprehensive proteome and the first phosphoproteome reveal extensive phosphorylation of carbohydrate metabolism in Cryptosporidium parvum sporozoites

This paper presents a comprehensive proteome and phosphoproteome of Cryptosporidium parvum sporozoites, revealing limited phosphorylation of core metabolic enzymes and emphasizing phosphorylation in regulatory and structural processes.

Efficient base editing and development in human embryos without chromosomal alterations

This study shows that base editing in human embryos produces efficient on-target changes without chromosomal abnormalities or large deletions, unlike CRISPR/Cas9-induced DSBs.

Harnessing within-cultivar variation to identify hidden genetic resistance using single plant-omics

The paper uses single plant-transcriptomics to analyze disease resistance in barley, identifying genetic variants associated with resistance to Fusarium graminearum.

Wheat and barley stripe rust pan-genome facilitates discovery of the predominant North American lineage's origin in somatic hybridization

The paper identifies the origin of the predominant North American Pst lineage, PstS18, as a somatic hybridization event between PstS1 and an unknown lineage.

The protein translation initiation machinery is targetable for developing fast-killing therapeutics against the zoonotic Cryptosporidium parvum

This paper identifies CpeIF4A as a novel drug target for anti-cryptosporidial therapeutics and shows that Roc-A inhibits parasite growth in vitro and in vivo.

New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions

The paper generates new alleles of BIK1 and PBL1 using CRISPR-Cas9 and shows their central role in pattern-triggered immunity, while highlighting pleiotropic effects of T-DNA insertions.

Deciphering of single-cell chromatin accessibility and transcriptome reveals the discrepancy for ex vivo human erythropoiesis

The paper analyzes ex vivo human erythropoiesis at single-cell chromatin accessibility and transcriptome levels to identify discrepancies and constraints in erythrocyte regeneration.

Origin and evolution of the bread wheat D genome

The paper analyzes the genetic composition and history of the bread wheat D genome using a pangenome of its donor species, revealing contributions from discrete subpopulations of Aegilops tauschii.

CATA: a comprehensive chromatin accessibility database for cancer

CATA is a database of chromatin accessible regions in cancer, providing annotations and integrative data for 24 cancer types from 410 tumor samples.

Transcriptome Landscape of Human Oocytes and Granulosa Cells Throughout Folliculogenesis

This study profiles the transcriptomes of human oocytes and granulosa cells across folliculogenesis stages, identifying stage-specific genes, cell interactions, and differences from mouse oocytes.