Guan Zhu

This paper develops a rapid host cell-free assay to screen anti-Cryptosporidium compounds, identifies five effective inhibitors, and links them to targetable enzymatic activities in sporozoites.

This paper presents a comprehensive proteome and phosphoproteome of Cryptosporidium parvum sporozoites, revealing limited phosphorylation of core metabolic enzymes and emphasizing phosphorylation in regulatory and structural processes.

The paper identifies genomic heterogeneity at the NDH2 locus in Cryptosporidium species that contributes to clofazimine resistance through adaptive recombination.

This paper identifies COWP4 and COWP6 as distinct oocyst wall proteins in Cryptosporidium parvum, showing COWP4 is essential for suture formation and infectivity while COWP6 links wall structure to host interaction.

This paper identifies CpeIF4A as a novel drug target for anti-cryptosporidial therapeutics and shows that Roc-A inhibits parasite growth in vitro and in vivo.

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.