Engineered Bacillus subtilis as oral probiotics to enhance clearance of blood lactate
Mengdi Yang, Noah T. Hutchinson, Ningyuan Ye, Hania Timek, Maria Jennings, Jianing Yin, Ming Guan, Zongqi Wang, Peiru Chen, Shaobo Yang, Justin D. Crane, Ke Zhang, Xuesong He, Jiahe Li
This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.
ACS Synthetic Biology · Dec 31, 2024Peer-reviewedSynthetic Biology