Xuesong He

The paper identifies a prophage-encoded enzyme that links bacterial metabolism, episymbiosis, and phage fitness by remodeling host structures and promoting symbiotic interactions.

This study identifies adhesin proteins in Nanosynbacteria that recognize specific host cell wall polysaccharides for recognition and attachment.

This study shows that enamel hypomineralization alters dental pulp and trigeminal nerve structure, transcriptome, and injury response without direct pulp exposure.

This study uses a 3D oral tissue model to investigate early gingival inflammation and disease progression by analyzing host-microbiome interactions.

The paper shows RNA phages are eliminated in dormant bacteria via ROS-mediated damage, but survival depends on genomic redundancy through co-infection.

This study identifies essential genes in Schaalia odontolytica using high-throughput transposon insertion sequencing.

This study shows Saccharibacteria suppress epithelial immune activation by clustering TLR2 via Type IV pili and endocytosis, reducing cytokine signaling and enabling long-term persistence in the oral microbiome.

This paper introduces a coculture model that simulates oral oxygen gradients to study microbial-host interactions and antibiotic efficacy.

This paper develops a 3D gingival model co-cultured with patient-derived microbiomes to study host-microbiome interactions and tissue homeostasis.

This study identifies two distinct Type IV pili in Saccharibacteria, showing their roles in host binding, competition, and motility.

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

This study uses expansion microscopy to differentiate adhesive interactions between microbial cells in biofilms at the single-cell level.

This study shows that Klebsiella outcompetes other microbes in oral and nasal communities during starvation, contributing to its persistence and potential pathogenicity.

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.