Shaobo Yang

This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

This paper engineers tumor-homing bacteria to display immune checkpoint-blocking nanobodies, showing enhanced tumor suppression in mouse models compared to traditional antibody therapies.

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.

The paper introduces enGager, a system that enhances ssDNA-mediated genome integration by fusing Cas9 with ssDNA-binding proteins, achieving up to 6-fold efficiency improvements for large transgene knock-in.