Author

Menglu Qian

Broad Institute

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

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Atsushi FukudaiD· 1 shared Bogdan BudnikiD· 1 shared Brian J. JosephiD· 1 shared Daniel A. MordesiD· 1 shared Francesco LimoneiD· 1 shared Gengle NiuiD· 1 shared Irune Guerra San JuaniD· 1 shared Jin HaoiD· 1 shared

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2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Atsushi FukudaORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintOct 11, 2021

Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons

Jin Hao, Michael F. Wells, Gengle Niu…·Kevin C. Eggan

This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.

17 citations

humanexperimental assay

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