BioinformaticsbioRxivPreprint
Biological foundation models illuminate annotation blind spots in evolutionarily divergent genomes
Toby B. Lanser, Sydney K. Caldwell, Gaspar A. Pacheco…·Hildreth Robert Frost
The paper introduces a hybrid annotation framework that improves cross-species protein similarity assignment and gene annotation in evolutionarily divergent genomes, expanding structural catalogs and improving single-cell immune cell state annotation in sea lamprey.
DOI 10.64898/2026.05.15.724572