Author

Michael Gapinske

University of Illinois Urbana-Champaign

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Pablo Pérez‐PiñeraiD· 3 shared Wendy S. WoodsiD· 3 shared Ananthan NambiariD· 2 shared Angelo MiskalisiD· 2 shared Gianna Elias· 2 shared Jackson Winter· 2 shared Michelle Stilger· 2 shared Nicholas C. GosstolaiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Pablo Pérez‐PiñeraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vivo CRISPR base editing for treatment of Huntington's disease

Shraddha Shirguppe, Michael Gapinske, Devyani Swami, Kyrollos Shenouda, Angelo Miskalis, Nicholas C. Gosstola, Daniela Del Bosque Siller, Isabelle Guerra, Pankaj Acharya, Dana Joulani, Maddie G. Szkwarek, Ananthan Nambiar, Abhishek Bhattacharjee, Anagha S. Dangi, Norah Odle, , Pablo Pérez‐Piñera

This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.

Nature Biomedical Engineering · Jul 29, 2026Peer-reviewedBioengineering

SPLICER: A Highly Efficient Base Editing Toolbox That Enables In Vivo Therapeutic Exon Skipping

Angelo Miskalis, Shraddha Shirguppe, Jackson Winter, Gianna Elias, Devyani Swami, Ananthan Nambiar, Michelle Stilger, Wendy S. Woods, Nicholas C. Gosstola, Michael Gapinske, M. Alejandra Zeballos C., Hayden J. Moore, Sergei Maslov, Thomas Gaj, Pablo Pérez‐Piñera

SPLICER improves exon skipping by editing both splice acceptor and donor sites, reducing aberrant splicing and enabling therapeutic applications in Alzheimer's disease.

Nature Communications · Nov 28, 2024Peer-reviewedBioengineering

Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members

Alex Finnegan, Somang Kim, Hu Jin, Michael Gapinske, Wendy S. Woods, Pablo Pérez‐Piñera, Jun S. Song

This study uses yeast to investigate how DNA methylation is regulated by DNMT3 family members and identifies sequence preferences and spatial patterns of methylation.

Nucleic Acids Research · Mar 13, 2020Peer-reviewedGenomics