Diffusion MRI based biomarkers reveal a Prolonged Pre Lesional Phase of Cerebral Small Vessel Disease
Prashanthi Vemuri, Mingzhao Hu, Emily S. Lundt, Michael G. Kamykowski, Robert I. Reid, Terry M. Therneau, Sheelakumari Raghavan, Petrice M. Cogswell, Michael Griswold, Beverly Gwen Windham, Clifford R. Jack, Ronald Carl Petersen, Jonathan Graff‐Radford
The paper identifies that diffusion MRI biomarkers show microstructural damage up to 16 years before white matter hyperintensities in cerebral small vessel disease.
bioRxiv · Mar 6, 2026 · PreprintNeuroscience