Michael P. Sheetz

Local Contractions Regulate E-Cadherin Adhesions, Rigidity Sensing and Epithelial Cell Sorting

The paper shows that local contractions regulate E-cadherin adhesions, rigidity sensing, and epithelial cell sorting through mechanical testing of neighboring cells.

Ligand Geometry Controls Adhesion formation via Integrin Clustering

This study shows that two-dimensional ligand geometry is required for adhesion formation on rigid substrates, with integrin clustering and unliganded integrins playing a key role.

Myosin filaments reversibly generate large forces in cells

The paper challenges current understanding of molecular motor force generation by showing that myosin filaments generate large reversible forces in cells through collective behavior.

Acto-myosin driven functional nanoclusters of GPI-anchored proteins are generated by integrin receptor signaling

This study identifies integrin receptor signaling as a driver of GPI-anchored protein nanoclusters through acto-myosin activity and vinculin coupling.