Michael P. Sheetz

SACHET tracks individual endosomes in live cells to quantify Rab conversion kinetics, showing rapid switching between Rab5 and Rab7 states across cell lines.

This study shows that restoring rigidity sensing in cancer cells via Tpm2.1 overexpression does not induce anoikis due to Akt activation and cell-cell interactions.

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.

This study investigates the holdase function of Escherichia coli DnaK chaperone using single-molecule assays, showing it stabilizes unfolded proteins and switches between holding and releasing states upon ATP binding.

The paper shows that cancer cells lose rigidity sensing due to cytoskeletal protein imbalances, and restoring these proteins can reverse transformed growth.