Author

Michelle Chan

Austrian Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Adam FreundiD· 1 shared Ahmed ShaabaniD· 1 shared Alexandra Eliassaf· 1 shared Andrea Ireland· 1 shared Arthur D. Levinson· 1 shared Aurélie ErnstiD· 1 shared Batsheva KeremiD· 1 shared Benjamin H. CooperiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenomics

Adam FreundORCID

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3 papers

Recent·Most cited

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology

Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

Michelle Chan, Han Yuan, Ilya Soifer, Tobias M. Maile, Rebecca Y. Wang, Andrea Ireland, Jonathon J. O’Brien, Jérôme Goudeau, Leanne Chan, Twaritha Vijay, Adam Freund, Cynthia J. Kenyon, Bryson D. Bennett, Fiona McAllister, David R. Kelley, , David G. Hendrickson

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

eLife · Feb 4, 2022Peer-reviewedGenomics

Dissecting Functional, Structural, and Molecular Requirements for Serotonin Release from Mouse Enterochromaffin Cells

Ahmed Shaaban, Frederike Maaß, Valentin Schwarze, Mari Lilith Lund, Sabine Beuermann, Michelle Chan, Christiane Harenberg, Gavin A. Bewick, Damien J. Keating, Fritz Benseler, Benjamin H. Cooper, Cordelia Imig

The paper investigates serotonin release mechanisms from mouse enterochromaffin cells using multiple techniques and finds that serotonin is primarily released from large dense-core vesicles with slow kinetics, similar to other endocrine cells.

bioRxiv · May 28, 2021 · PreprintNeuroscience