Adam Freund

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

The paper quantifies diet-dependent genetic contributions to body weight in mice and identifies loci associated with age- and diet-dependent body weight variation.

This study develops a high-dimensional phenotyping platform to evaluate physiological aging and resilience in mice, finding that aging begins early and resilience declines with age.

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.