Aurélie Ernst

This study integrates spatial and multi-omic data from bladder cancer patients to show L1 retrotransposition drives genomic instability, ecDNA formation, and a viral mimicry response.

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

HIPSD&R-seq profiles genomic copy number and transcriptomes in thousands of cells, enabling rare clone detection in human cell models and primary tissue.

This study compares the reprogramming dynamics of pluripotent and trophoblast stem cell states using multi-omics analysis, revealing distinct trajectories and reprogramming markers.

The paper investigates fibrotic scarring in CNS lesions across species and lesion types, finding pericyte-derived fibrosis as a conserved mechanism.

This paper introduces a method to generate localized DNA double-strand breaks in cell populations using UV-irradiation with photomasks, enabling the study of genome rearrangements and DNA damage response.