BiochemistrybioRxivPreprint
Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism
Riley J. Wedan, Pieter R. Norden, Morgan T. Canfield…·Sara M. Nowinski
The paper identifies malonate as an endogenous intermediate supporting mitochondrial fatty acid synthesis and oxidative phosphorylation, showing ACC1-dependent synthesis from glucose.
DOI 10.64898/2026.05.22.727248