Cancer BiologybioRxivPreprint
Pharmacological Modulation of TRIB2 Stability in Melanoma Reveals CDK12/13 as Dominant Regulators and Potential Therapeutic Targets
Víctor Mayoral-Varo, Alba Orea‐Soufi, Lucía Jiménez…·Wolfgang Link
This study identifies CDK12/13 as key regulators of TRIB2 stability in melanoma and presents three classes of compounds that effectively eliminate TRIB2 with higher potency than afatinib.
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