Min Wang

A vascular chip for disease-relevant flow shear stress topology

This paper introduces a vascular chip that enables controlled experimentation with disease-relevant wall shear stress topology, revealing its effects on endothelial mechanics and function.

FLASH Radiotherapy Mitigates Radiation-Induced Lymphopenia and Prevents Immunosuppression via Chk1-STAT3 Axis Modulation in a Preclinical Thoracic Irradiation Model

This study shows FLASH radiotherapy reduces lymphocyte apoptosis and prevents immunosuppression by modulating the Chk1-STAT3 pathway in a preclinical model.

Healthcare Infrastructure Shapes Evolutionary Trade-offs and Geographic Dissemination of Multidrug-Resistant Acinetobacter baumannii

This study shows how hospital network structure influences the evolution and spread of drug-resistant bacteria, identifying two distinct evolutionary strategies in Acinetobacter baumannii.

A global viromic survey reveals unprecedented viral diversity within ammonium-oxidizing archaea and related lineages

The paper presents the first genomic catalogue of viruses and mobile genetic elements associated with Nitrososphaeria, revealing novel viral families and insights into their evolution and adaptation.

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Spermatogonia derived RpS13 non-autonomously regulates the cyst cell differentiation via Rho1-mediated adhesion junctions in Drosophila testis

Genomic feature of filled regions of telomere-to-telomere genomes in five model species

The paper compares T2T genomes with older versions across species to analyze genomic features in filled regions, finding distinct patterns between plants and animals.

Construction of a third NAD+ de novo biosynthesis pathway

This paper describes a new NAD+ de novo biosynthesis pathway in E. coli that starts from chorismate and demonstrates its utility in cofactor engineering for chemical production.

Essential role of Bone morphogenetic protein 15 in porcine ovarian and follicular development and ovulation

This study shows that BMP15 is essential for porcine ovarian and follicular development, as its knockdown leads to reduced fertility and ovarian dysfunction.

Decomposing the Apoptosis Pathway Into Biologically Interpretable Principal Components

The paper improves PCA for biological data by automating a graphical Bayesian method to identify significant principal components with biological interpretations, applied to proteomics data from acute myeloid leukemia patients.