Anna Malovannaya

This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.

This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.

This study shows that deleting EGR3 in Kcna1-null mice rescues seizures, behavior, and brain pathology, linking early seizures to long-term transcriptional changes.

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

This study identifies proteomic changes in CREM-IbΔC-X transgenic mice with persistent atrial fibrillation, showing a shift from metabolic to profibrotic gene expression programs with age.

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.

This study generates and characterizes a rat model with a truncating Magel2 mutation, revealing altered behavioral and physiological traits consistent with human neurodevelopmental disorders.

The paper shows that partial loss of CFIm25, a protein regulated by NUDT21, causes learning deficits and molecular changes in neurons.

This study shows that 3' sequence identity is not required for the established function of miR-146a in myeloid cells in vivo.