Yong Chen

Adipocyte Kindlin-2 Coordinates an E-cadherin/β-catenin/IGFBP2 Endocrine Axis to Regulate Skin Regeneration and Diabetic Wound Healing

This study identifies adipocyte Kindlin-2 as a regulator of skin wound healing through an endocrine axis involving E-cadherin, β-catenin, and IGFBP2.

Importance of tribo-pairs to mimic blinking in vitro for dry eye disease research

This study evaluates tribo-pairs for simulating blinking in dry eye disease research, finding that porcine eyelid-eyeball pairs better mimic physiological friction than glass alternatives.

A standardized, open-source, portable model for noninvasive joint injury in mice

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

MTARC1 Regulates Lipid Droplet Degradation via Phospholipid Remodeling in Metabolic Fatty Liver Disease

This study shows MTARC1 inactivation reduces hepatic triglyceride accumulation and liver injury by promoting lipid droplet degradation through phospholipid remodeling.

GRIPT: A novel case-control analysis method for Mendelian disease gene discovery

GRIPT is a case-control analysis method for NGS data that improves disease gene discovery, particularly in highly heterogeneous Mendelian diseases.

Improved performance of microbial fuel cells through addition of trehalose lipids

This paper adds trehalose lipid to microbial fuel cells (MFCs) to enhance power output by improving electron transfer and reducing internal resistance.

RSQ: a statistical method for quantification of isoform-specific structurome using transcriptome-wide structural profiling data

RSQ quantifies isoform-specific structurome by modeling read distribution across isoforms and RNA conformations, enabling comparison between conditions and analysis of conformational variation.