Luisa M. Solis Soto

This study compares spatial immune architectures in tumor and tumor-adjacent tissues of early-stage NSCLC, finding distinct immune cell densities, spatial patterns, and associations with genomic features and patient outcomes.

This study uses CyTOF to profile circulating tumor cells in SCLC patients, identifying subtype-specific markers and treatment response correlations.

This study evaluates tissue factor (TF) and TROP2 expression in penile squamous cell carcinoma (PSCC) and links TF to HPV-independent, p53-aberrant disease while TROP2 correlates with HPV-associated PSCC.

This study compares imaging-based spatial transcriptomics platforms using FFPE tumor samples, finding differences in performance and highlighting factors affecting data quality.

S2Omics automatically selects regions of interest from histology images to maximize molecular information content in spatial omics experiments, improving reproducibility and downstream biological discovery.

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

This paper introduces LSGI, a framework to identify interpretable spatial gradients in spatial transcriptomics data, revealing pathway gradients in glioblastoma and across 87 tumor datasets.