Author

Moli Sang

Shandong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Jiawei GuoiD· 2 shared Peiyuan Feng· 2 shared Shengying LiiD· 2 shared Wei ZhangiD· 2 shared Wencheng Ma· 2 shared Binju WangiD· 1 shared Bo HuiD· 1 shared Ce GengiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Jiawei GuoORCID

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3 papers

Recent·Most cited

Tryptophan Chemistry Driven by a Widespread Cytochrome P422 Enzyme Family

Wencheng Ma, Qian Wang, Qingyu Yang, Zhaojie Teng, Xiao Han, Moli Sang, Qiuyu Li, Ruili Wang, Peiyuan Feng, Jingyi Zhong, Yan Zhang, Yifeng Wei, Li Jiang, Frederick Peter Guengerich, Wei Zhang

The paper identifies a widespread cytochrome P422 enzyme family that performs four novel tryptophan transformations, revealing new enzymatic capabilities and introducing a computational tool for HBP discovery.

bioRxiv · Dec 13, 2025 · PreprintBiochemistry

Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis

Jiawei Guo, Qiaoyu Zhang, Yang Shen, Fangyuan Cheng, Moli Sang, Xuan Wang, Yunjun Pan, Mingyu Liu, Hao‐Bing Yu, Bo Hu, Sheng Wang, Liangzhen Zheng, Ce Geng, Chaofan Yang, Lianzhong Luo, , Xingwang Zhang

This paper identifies the enzymatic mechanism for forming the gamma-thiolactone ring in thiolactomycin biosynthesis, revealing the roles of TlnCCy and TlnA.

Journal of the American Chemical Society · Jun 20, 2025Peer-reviewedBiochemistry

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

Moli Sang, Qingyu Yang, Jiawei Guo, Peiyuan Feng, Wencheng Ma, Shengying Li, Wei Zhang

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

bioRxiv · May 3, 2024 · PreprintBiochemistry