PathologyProtein SciencePeer-reviewed
Polyglutamine expansion induced dynamic misfolding of Androgen Receptor
Laurens W.H.J. Heling, Vahid Sheikhhassani, Julian Ng…·Alireza Mashaghi
This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.
1 citation