Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis
Simran Singh, Ashish Kumar, Sudipta Paul, Mriganka Sarkar, Santhosh Duraisamy, H.N. Yadav, Seema Kuldeep, Soumita Bhaumik, Kunj Kumar Prajapati, Saahiba Thaleshwari, Anuj Gargya, Tamojit Santra, Sonal Amit, Rashmi Parihar, Santosh Kumar Misra, , Sai Prasad Pydi
This study shows that activating Gq-signaling in islet macrophages impairs β-cell insulin secretion via the AMPK-sphingolipid axis, revealing a new immune-endocrine communication mechanism.
bioRxiv · Oct 29, 2025 · PreprintPhysiology