PhysiologybioRxivPreprint
Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis
Simran Singh, Ashish Kumar, Sudipta Paul…·Sai Prasad Pydi
This study shows that activating Gq-signaling in islet macrophages impairs β-cell insulin secretion via the AMPK-sphingolipid axis, revealing a new immune-endocrine communication mechanism.
DOI 10.1101/2025.10.29.680858