Muscle-to-Bone CX3CL1 Signaling Promotes Skeletal Repair Through CX3CR1+ Osteoprogenitors
Koji Ishikawa, Choiselle Marius, Eijiro Shimada, Puvi Nadesan, Tuyet Nguyen, Mahoko Ishikawa, Jiaul Hoque, Xinyi Ma, Makoto Nakagawa, N ALLEN, Koki Abe, Philip Varnadore, Tomokazu Souma, Shyni Varghese, Yasuhiro Yahara, , Benjamin Aaron Alman
This study identifies a muscle-to-bone signaling pathway where CX3CL1 from muscle endothelial cells promotes bone repair via CX3CR1-expressing osteoprogenitors.
bioRxiv · May 27, 2026 · PreprintCell Biology