Shyni Varghese

This study develops HA Tau nanosponges that reduce systemic inflammation and cognitive decline in aged mice by sequestering inflammatory proteins without suppressing immunity.

This paper develops a vascularized tumor organoid platform to model patient-specific immunotherapy responses and identifies hyperangiogenic signaling as a barrier to T cell infiltration.

This study identifies a muscle-to-bone signaling pathway where CX3CL1 from muscle endothelial cells promotes bone repair via CX3CR1-expressing osteoprogenitors.

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.