Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant.
L. Yammine, B. Picatoste, N. Abdullah, R. Leahey, N. Gomez-Banoy, C. Rosselot, J. Wen, M. D. Goncalves, J. C. Lo, A. Garcia-Ocana, T. E. McGraw
This study investigates the impact of a GIPR variant on glucose homeostasis using a mouse model, finding altered intracellular trafficking and increased GIP sensitivity.
bioRxiv · May 12, 2020Physiology