J. Wen

A Multitrait Genome-Wide Association Study Reveals a Requirement for the Strigolactone Receptor DWARF14 in Optimal GOLVEN10 Signaling

This study identifies a genetic link between strigolactone signaling and GLV10 responsiveness in Medicago truncatula through genome-wide association and mutant analysis.

Inverse Reinforcement Learning to Study Motivation in Mouse Behavioral Paradigms

This paper applies inverse reinforcement learning to directly infer the underlying motivations driving mouse behavior in behavioral paradigms.

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation

This paper introduces UNITO, a deep learning framework for automated cytometric gating that matches human performance and provides interpretable results without requiring manual input.

Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

This study investigates whether bumblebees use means-end comprehension in string-pulling tasks and finds they rely on visual matching and associative learning instead.

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

Pathogenic IgE-fated memory B cell responses retain functional plasticity

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation

This study shows that a high-cholesterol diet in zebrafish leads to hypercholesterolemia and fasting-induced liver triglyceride accumulation, with lipid accumulation in adipocytes contributing to hepatic steatosis.

A phylogenomic approach, combined with morphological characters gleaned via machine learning, uncovers the hybrid origin and biogeographic diversification of the plum genus

This study combines phylogenomic and machine learning analyses to reveal hybrid origins and biogeographic diversification patterns in the plum genus.

Cellular gibberellin dynamics govern indeterminate nodule development, morphologyand function

This study identifies cellular gibberellin dynamics as a positive regulator of nodule growth and development in legumes, distinct from lateral root formation.

GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells

The paper uses proximity mapping to show AMPK regulates GLUT4 subcellular localization in muscle cells by controlling exocytosis and endocytosis.

Nodule-specific Cu+-chaperone NCC1 is required for symbiotic nitrogen fixation in Medicago truncatula root nodules

This study identifies MtNCC1 as a nodule-specific Cu+-chaperone essential for symbiotic nitrogen fixation in Medicago truncatula, showing reduced nitrogenase and copper-dependent cytochrome c oxidase activity in mutants.

Efficient transgene-free genome editing in plants in the T0 generation based on a co-editing strategy

This study develops a co-editing strategy to generate transgene-free, gene-edited plants in the T0 generation using Agrobacterium-mediated transient expression of CBE/gRNA and Cas12a/crRNA-GFP.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Light sensitive short hypocotyl (LSH) confer symbiotic nodule identity in the legume Medicago truncatula

The paper identifies LSH1/LSH2 transcription factors as regulators of nodule identity in Medicago truncatula, distinct from lateral root identity.

Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy

This study shows that mutating TSC2 at S1365 enhances T-cell effector function and memory formation, improving adoptive T-cell therapy for cancer.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Endogenous RNAi silences a burgeoning sex chromosome arms race

This study shows endogenous RNAi suppresses X-linked meiotic drive loci in Drosophila simulans, revealing rapid evolution of hpRNA-target interactions and their role in sex chromosome conflict.

Target sequence capture data shed light on the deeper evolutionary relationship on the subgenus Chamaecerasus of Lonicera (Caprifoliaceae)

This study uses target sequence capture data to analyze the evolutionary relationships within the subgenus Chamaecerasus of Lonicera, revealing polyphyly and proposing taxonomic revisions.

Multiscale functional connectivity patterns of the aging brain learned from rsfMRI data of 4,259 individuals of the multi-cohort iSTAGING study

The paper develops a brain age prediction model using multiscale functional connectivity from rsfMRI data of 4,259 individuals, showing that multiscale measures improve prediction and that brain age gaps correlate with cognitive and clinical measures.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

A wheat resistosome defines common principles of immune receptor channels

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

Transcriptomics informs design of a planar human enterocyte culture system that reveals metformin enhances fatty acid export

The paper develops a human enterocyte culture system to study lipid handling and finds metformin enhances fatty acid export by promoting fatty acid oxidation.

Organization and dynamics of the SpoVAEa protein, and its surrounding inner membrane lipids upon germination of Bacillus subtilis spores

The paper tracks the dynamics of SpoVAEa and its surrounding inner membrane during Bacillus subtilis spore germination, showing a functional microdomain that disappears with germination.

Heat activation and inactivation of bacterial spores. Is there an overlap?

This paper investigates heat activation and inactivation of Bacillus subtilis spores, finding that specific temperatures promote germination while others cause damage.

Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge

The paper identifies CAD-induced pyrimidine synthesis and ribosomal biogenesis as critical for rapid recall responses in memory CD8+ T cells.

Tropical-temperate dichotomy falls apart in the Asian Palmate Group of Araliaceae

The study evaluates the climatic characterization of the Asian Palmate Group genera, finding little support for the tropical-temperate dichotomy due to climatic complexity and transitional regions.

Phylogenomic analyses in the apple genus Malus s.l. reveal widespread hybridization and allopolyploidy driving the diversifications, with insights into the complex biogeographic history in the Northern Hemisphere

{micro}-Theraphotoxin-Pn3a inhibition of Cav3.3 channels reveals a novel isoform-selective drug binding site

This study identifies Pn3a as a subtype-selective inhibitor of CaV3.3 T-type calcium channels, revealing a novel isoform-specific binding site with therapeutic potential.

TET1 controls Cxcl1 induction by DNA demethylation and promotes neutrophil recruitment during acute lung injury

This study shows TET1 facilitates DNA demethylation of the Cxcl1 promoter, enabling its induction and neutrophil recruitment during acute lung injury.