SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression
N. Arshad, M. Laurent-Rolle, W. S. Ahmed, J. C.-C. Hsu, S. M. Mitchell, J. Pawlak, D. Sengupta, K. H. Biswas, P. Cresswell
This paper identifies two distinct mechanisms by which SARS-CoV-2 accessory proteins ORF7a and ORF3a downregulate MHC-I surface expression to evade immune detection.
bioRxiv · May 17, 2022Immunology