ImmunologybioRxiv
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression
N. Arshad, M. Laurent-Rolle, W. S. Ahmed…·P. Cresswell
This paper identifies two distinct mechanisms by which SARS-CoV-2 accessory proteins ORF7a and ORF3a downregulate MHC-I surface expression to evade immune detection.
DOI 10.1073/pnas.2208525120