Loss of Usp22 enhances histone H2B monoubiquitination and stimulates intracellular and systemic interferon immunity
N. Dietlein, X. Wang, E. Rodriguez Correa, B. Erbil, D. B. Lipka, Y. Begus-Nahrmann, R. L. Kosinsky, S. A. Johnsen, T. H. Winkler, H.-R. Rodewald
The paper shows that loss of Usp22 increases H2Bub1 levels, leading to enhanced ISG expression and IFN immunity in mice.
bioRxiv · Apr 9, 2021 · PreprintImmunology