Endothelial cell senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling
R. Ramadhiani, K. Ikeda, K. Miyagawa, G. R. T. Ryanto, N. Tamada, Y. Suzuki, K.-i. Hirata, N. Emoto
This study shows that endothelial cell senescence worsens pulmonary hypertension by activating Notch signaling in smooth muscle cells through juxtacrine interactions.
bioRxiv · Feb 2, 2021 · PreprintCell Biology