K. Ikeda

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via PDH regulation

The paper shows hyperosmotic stress triggers rapid metabolic changes in cells through mitochondrial PDH regulation, maintaining ATP levels and survival.

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

This study identifies Semaphorin 3G as a factor that worsens joint inflammation by promoting macrophage accumulation and proliferation in RA synovium.

Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2

The paper identifies immunological features, including B cell frequencies and CD8+ T cell activation, that correlate with antibody response strength to the BNT162b2 mRNA vaccine.

Endothelial cell senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling

This study shows that endothelial cell senescence worsens pulmonary hypertension by activating Notch signaling in smooth muscle cells through juxtacrine interactions.

Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

This study identifies SLC25A44 as a mitochondrial BCAA carrier essential for metabolic flexibility and optimal fever response through enhanced mitochondrial BCAA oxidation and thermogenesis.

On-site eDNA detection of species using ultra-rapid mobile PCR

This study develops an ultra-rapid mobile PCR method for on-site eDNA detection of aquatic species, demonstrating high detectability and faster results than traditional lab-based approaches.

Effects of species traits and ecosystem characteristics on species detection by eDNA metabarcoding in lake fish communities

This study evaluates how species traits and ecosystem characteristics affect eDNA detection rates in lake fish communities across Japan.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

TGF-β inhibitor accelerates BMP4-induced cochlear gap junction formation during in vitro differentiation of embryonic stem cells

This study shows that the TGF-β inhibitor SB431542 accelerates BMP4-induced gap junction formation in CX26GJCs derived from mouse iPSCs, improving their yield for therapeutic applications.

Cortisol levels adter cold exposure are independent of adrenocorticotropic hormone stimulation

This study shows that cortisol levels after cold exposure are not correlated with ACTH levels in human autopsies or in cell culture experiments.

Enigmatic Diphyllatea eukaryotes: Culturing and targeted PacBio RS amplicon sequencing reveals a higher order taxonomic diversity and global distribution

The paper cultures Diphyllatea strains, amplifies full 18S rRNA genes using PacBio RS II, and identifies three clades, revealing two morphotypes and broader global distribution.