Molecular architecture of a membrane-spanning hormone acyltransferase required for metabolic regulation
M. B. Campana, F. J. Irudayanathan, T. R. Davis, K. R. McGovern-Gooch, R. Loftus, M. Ashkar, N. Escoffery, M. Navarro, M. A. Sieburg, S. nangia, J. L. Hougland
The paper presents a structural model of GOAT, an MBOAT enzyme, using co-evolutionary constraints and computational modeling validated by biochemistry, revealing a novel acylation mechanism within a transmembrane channel.
bioRxiv · Feb 28, 2019 · PreprintBiochemistry