BiochemistrybioRxivPreprint
A remarkably specific ligand reveals ghrelin O-acyltransferase interacts with extracellular peptides and exhibits unexpected cellular localization for a secretory pathway enzyme
M. B. Campana, T. R. Davis, E. R. Cleverdon…·J. Hougland
This study identifies a specific ligand that shows GOAT interacts with extracellular ghrelin and facilitates its internalization, revealing new insights into its catalytic mechanism and signaling role.
DOI 10.1101/2021.06.01.446150