M. Navarro

In-Depth Mapping of DNA-PKcs Signaling Uncovers Conserved Features of Its Kinase Specificity

This study identifies a novel phosphorylation motif used by DNA-PKcs, revealing its role in regulating splicing factors and transcriptional regulators across species.

MetFinder: a neural network-based tool for automated quantitation of metastatic burden in histological sections from animal models

MetFinder uses a deep neural network to automate metastasis burden quantification in histological sections from mouse models, improving throughput and resolution compared to current methods.

Gut microbiota and age shape susceptibility to clostridial enteritis in lorikeets under human care

The paper identifies gut microbiota and age factors associated with susceptibility to clostridial enteritis in lorikeets using 16S rRNA sequencing and machine learning models.

Assessment of the use and quick preparation of saliva for rapid microbiological diagnosis of COVID-19.

This study compares RNA extraction and heat-inactivation methods for RT-PCR detection of SARS-CoV-2 in saliva, finding that heat-inactivation can achieve good sensitivity and specificity.

Healthcare professionals and students awareness of Chagas disease: design and validation of ChaLKS (Chagas Level of Knowledge Scale)

This paper develops and validates two knowledge assessment scales for Chagas disease among healthcare professionals and aid workers, showing significant knowledge gaps between healthcare and non-healthcare sectors.

Molecular architecture of a membrane-spanning hormone acyltransferase required for metabolic regulation

The paper presents a structural model of GOAT, an MBOAT enzyme, using co-evolutionary constraints and computational modeling validated by biochemistry, revealing a novel acylation mechanism within a transmembrane channel.

The Notch and EGFR signaling regulate caspase inhibitor Diap1 to match supply with intestinal demand

The paper shows that Notch and EGFR signaling regulate Diap1 to control enteroblast cell death and survival in Drosophila intestine, balancing tissue renewal and tumor suppression.