Author

F. J. Irudayanathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

J. L. Hougland· 1 shared J. Lin· 1 shared J. Zarzar· 1 shared K. R. McGovern-Gooch· 1 shared M. A. Sieburg· 1 shared M. Ashkar· 1 shared M. B. Campana· 1 shared M. Navarro· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

J. L. Hougland

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2 papers

Recent·Most cited

Divining Deamidation and Isomerization in Therapeutic Proteins: Effect of Neighboring Residue

F. J. Irudayanathan, J. Zarzar, J. Lin, S. Izadi

This study identifies key molecular indicators of asparagine deamidation and aspartic acid isomerization in therapeutic antibodies and proposes a physics-based model to predict their propensity.

bioRxiv · Jul 26, 2021 · PreprintBiochemistry

Molecular architecture of a membrane-spanning hormone acyltransferase required for metabolic regulation

M. B. Campana, F. J. Irudayanathan, T. R. Davis, K. R. McGovern-Gooch, R. Loftus, M. Ashkar, N. Escoffery, M. Navarro, M. A. Sieburg, S. nangia, J. L. Hougland

The paper presents a structural model of GOAT, an MBOAT enzyme, using co-evolutionary constraints and computational modeling validated by biochemistry, revealing a novel acylation mechanism within a transmembrane channel.

bioRxiv · Feb 28, 2019 · PreprintBiochemistry