A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity
J. Xia, A. Siffert, O. Torres, J. Banasiak, K. Pakula, J. Ziegler, S. Rosahl, N. Ferro, M. Jasinski, T. Hegedus, M. Geisler
The paper shows that mutation of L704 in ABCG36 affects substrate specificity by altering transport of IBA and CLX, with molecular dynamics supporting a quality control role.
bioRxiv · Apr 22, 2024Biochemistry