J. Xia

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity

This study analyzes giant virus dynamics using metagenomic data, revealing year-round recovery and distinct population dynamics linked to microdiversity and niche breadth.

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

The paper identifies 44 compounds with >50% inhibitory effects against Toxoplasma gondii bradyzoites using a high-throughput screen and characterizes one compound's activity.

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

The paper shows that mutation of L704 in ABCG36 affects substrate specificity by altering transport of IBA and CLX, with molecular dynamics supporting a quality control role.

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii.

This paper identifies a Toxoplasma gondii isolate that constitutively expresses bradyzoite regulators and readily differentiates into mature bradyzoites under stress, providing a new in vitro model for studying chronic infection.

The transcription factor OsbZIP48 governs rice responses to zinc deficiency

This study identifies OsbZIP48 as a transcription factor critical for rice's response to zinc deficiency, showing it regulates zinc transporter genes through direct promoter binding.

Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

Characterization of sinking and suspended microeukaryotic communities in spring Oyashio waters

This study characterizes sinking and suspended microeukaryotic communities in Oyashio waters using 18S rDNA metabarcoding, revealing depth-related differences and functional roles in the biological carbon pump.

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

Ultrafast Power Doppler Ultrasound Enables Longitudinal Tracking of Vascular Changes that Correlate with Immune Response After Radiotherapy

This paper uses ultrafast power Doppler ultrasound to track vascular changes in tumors after radiotherapy, showing correlation with immune response.

TEAD1 regulates ITGA1 and ITGA2 to control prostate cancer progression

This study identifies TEAD1 as a regulator of ITGA1 and ITGA2 in prostate cancer, showing their loss promotes tumor progression via TGFβ1-driven EMT.

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.

Dynamics of Innate Immune Response Due to Bacteria-Induced Pulpitis

This study investigates the dynamics of innate immune response in pulpitis by analyzing immune cell composition and bacterial infiltration in mouse dental pulp over time.

Sex-specific deubiquitylation drives immune-related neurodegeneration in Drosophila

This study shows that sex-specific deubiquitylation by Trabid in Drosophila influences neurodegeneration linked to immune responses and protein accumulation.

Medicago truncatula ABCG40 is a cytokinin importer that negatively regulates lateral root density and nodule number

This study identifies MtABCG40 as a cytokinin importer in Medicago truncatula that reduces lateral root density and nodule number by affecting CK signaling and auxin response.

Chemical inhibition of PIN auxin transporters by the anti-inflammatory drug Naproxen

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

The RNA m6A reader YTHDF1 promotes hematopoietic malignancy by maintaining oncogenic translation

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

Spatial confinement modulates macrophage response in microporous scaffolds

This study investigates how spatial confinement in microporous scaffolds affects macrophage polarization and inflammatory response.

Recovery of structural integrity of epithelial monolayer in response to massive apoptosis-induced defects

This study shows that epithelial monolayers recover structural integrity after apoptosis-induced defects through enhanced cell spreading, migration, and traction forces.

Multimodal electrocorticogram active electrode array based on zinc oxide-thin film transistors

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

A phospho-switch provided by LRR receptor-like kinase, ALK1/QSK1/KIN7, prioritizes ABCG36/PEN3/PDR8 transport toward defense

This study identifies a phospho-switch mechanism involving ALK1 and ABCG36 that prioritizes defense-related transport over growth in Arabidopsis.

Resource requirements for ecotoxicity testing: A comparison of traditional and new approach methods

This study compares resource requirements of traditional and new approach methods in ecotoxicity testing, finding NAMs are cheaper, use fewer animals, and are faster.

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

WESTPA 2.0: High-performance upgrades for weighted ensemble simulations and analysis of longer-timescale applications

The paper introduces WESTPA 2.0, an upgraded software package for weighted ensemble simulations, enhancing efficiency and analysis of longer-timescale applications.

E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

Exploration of molecular mechanism underlying the self-flocculation of Zymomonas mobilis through comparative omics analyses and experimental validations for developing robust production systems

This study identifies genetic mutations in Zymomonas mobilis that cause self-flocculation by disrupting gene function and increasing c-di-GMP levels, enabling improved biomass recovery and productivity.

Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii

This paper identifies and characterizes a phage-derived depolymerase, Dpo71, which enhances antibiotic efficacy and immune response against multidrug-resistant Acinetobacter baumannii.

Mechanistic Insights of High Temperature-Interfered Meiosis in Autotetraploid Arabidopsis thaliana

This study investigates how high temperatures affect meiosis in autotetraploid Arabidopsis thaliana, revealing that heat stress disrupts chromosome axis stability and meiotic recombination.

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

Fast 3D printing of large-scale biocompatible hydrogel models

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.