Author

T. Hegedus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. L. Lukacs· 2 shared H. Tordai· 2 shared N. Soya· 2 shared R. Padanyi· 2 shared A. Enyedi· 1 shared A. Malnasi-Csizmadia· 1 shared A. Mike· 1 shared A. Premchandar· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

G. L. Lukacs

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS CoV-2 Envelope protein alters calcium signaling via SERCA interactions

B. Berta, H. Tordai, G. L. Lukacs, B. Papp, A. Enyedi, R. Padanyi, T. Hegedus

This study shows that SARS-CoV-2 E protein interacts with SERCA2b and regulins, altering calcium homeostasis and potentially contributing to viral pathogenesis.

Scientific Reports · Sep 11, 2024Peer-reviewedCell Biology

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

G. L. Lukacs, N. Soya, H. Xu, A. Roldan, Z. Yang, H. Ye, A. Premchandar, F. Jiang, G. Veit, S. P. C. Cole, J. C. Kappes, T. Hegedus

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

bioRxiv · Oct 19, 2023Biophysics

Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1

R. Padanyi, B. Farkas, H. Tordai, B. Kiss, H. Grubmuller, N. Soya, G. Lukacs, M. Kellermayer, T. Hegedus

This study combines nanomechanics and HDX to identify allosteric binding sites in {Delta}F508-CFTR NBD1, revealing how BIA stabilizes the protein.

bioRxiv · Aug 20, 2021Biophysics

Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling

M. C. Földi, K. Pesti, K. Zboray, T. Hegedus, A. Malnasi-Csizmadia, P. Lukacs, A. Mike

This study reveals that riluzole inhibits sodium channels through non-blocking modulation rather than block, using conformation-selective photolabeling to identify binding sites and mechanisms.

bioRxiv · May 5, 2020Pharmacology & Toxicology