Myelin-reactive B cells exacerbate the severity of CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner.
M. R. Fazazi, P. M. I. A. Doss, R. Pereira, N. Fudge, A. Regmi, C. Joly-Beauparlant, I. Akbar, A. P. Yeola, B. Mailhot, J. Baillargeon, P. Grenier, N. Bertrand, S. Lacroix, A. Droit, C. S. Moore, , M. Rangachari
This study shows that MOG-specific B cells worsen CD4+ T cell-driven CNS autoimmunity by promoting Th17 and Tph cell accumulation via IL-23.
bioRxiv · Sep 6, 2023Immunology