BiochemistrybioRxivPreprint
The mechanism of nicotinamide phosphoribosyltransferase whereby positive allosteric modulation elevates cellular NAD+
K. M. Ratia, Z. Shen, J. Gordon-Blake…·G. R. J. Thatcher
This study identifies the mechanism by which NAMPT is activated by positive allosteric modulators, revealing how this enhances NAD+ biosynthesis and regulates NAM binding.
DOI 10.1101/2022.10.21.513220