A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis
S. Haupt, N. Gleim, A. Ahadova, H. Bläker, M. von Knebel Doeberitz, M. Kloor, V. Heuveline
This paper develops a computational model to simulate colonic crypt evolution in Lynch syndrome, showing the importance of stem cell dynamics and MMR deficiency in CRC development.
bioRxiv · Dec 29, 2020Cancer Biology