Gene Therapy for Follistatin Mitigates Systemic Metabolic Inflammation and Post-Traumatic Osteoarthritis in High-Fat Diet-Induced Obese Mice
R. Tang, N. Harasymowicz, C.-L. Wu, K. Collins, Y.-R. Choi, S. Oswald, F. Guilak
This study shows that FST gene therapy reduces metabolic inflammation and post-traumatic OA in obese mice by improving mitochondrial function and adipose tissue browning.
bioRxiv · Apr 25, 2019Physiology