R. Tang

PIEZO1-Mediated Mechanotransduction Regulates Collagen Synthesis on Nanostructured 2D and 3D Models of Fibrosis

This study shows PIEZO1 regulates collagen synthesis in hASCs based on substrate architecture, with YAP/TAZ translocation and collagen production being independent outcomes of PIEZO1 activation.

Aging represses lung tumorigenesis and alters tumor suppression

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels

This paper develops core/shell microgels for in situ cartilage tissue engineering, enabling immediate implantation and spontaneous fusion of cell condensates without prior in vitro culture.

Cyr61 delivery promotes angiogenesis during bone fracture repair

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells

This paper develops a method to generate genetically engineered adipocytes from murine iPSCs using CRISPR-Cas9 and tests their engraftment and functional properties in vivo.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis.

This study shows Serpine1 inhibits Th1 cell pathogenicity in EAE by promoting Tim-3 expression and function.

TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells

This study shows TRPML1 activation reduces lysosomal storage in CLN3-deficient retinal cells but does not restore BMP levels.

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcϵRIα expression

This study identifies FCER1A-AS, an antisense lncRNA, as a regulator of FcϵRIα expression, which is critical for anaphylactic reactions.

4D Cell-Condensate Bioprinting

This paper introduces a 4D bioprinting method to create shape-morphing cell condensate bilayers with predefined geometries, demonstrating its use in forming complex shapes like 'C' and helix-shaped cartilage-like tissues from hMSCs.

MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.

Adipose Tissue is a Critical Regulator of Osteoarthritis

This study shows adipose tissue, not body weight, drives osteoarthritis progression through paracrine signaling in a mouse model of lipodystrophy.

G-baToN: a versatile reporter system for cancer cell-stromal cell interactions.

This paper introduces G-baToN, a reporter system that labels cell-cell interactions through fluorescent protein transfer, enabling study of cancer-stromal cell interactions and other biological processes.

Partial loss of colonic primary cilia promotes inflammation and carcinogenesis

This study shows that reduced colonic primary cilia in fibroblasts promotes inflammation and cancer in mouse models and human disease.

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.

Long non-coding RNA GRASLND enhances chondrogenesis via suppression of interferon type II signaling pathway

This study identifies GRASLND as a primate-specific lncRNA that enhances chondrogenesis by suppressing interferon type II signaling in mesenchymal stem cells.

Gene Therapy for Follistatin Mitigates Systemic Metabolic Inflammation and Post-Traumatic Osteoarthritis in High-Fat Diet-Induced Obese Mice

This study shows that FST gene therapy reduces metabolic inflammation and post-traumatic OA in obese mice by improving mitochondrial function and adipose tissue browning.

The gut microbiota regulates mouse biliary regenerative responses

This study shows that gut microbiota influences biliary regenerative responses in mice, with butyrate playing a role in inhibiting fibrosis.

Changes in the Physicochemical Properties and Microbial Communities of Rhizospheric Soil after Cassava/Peanut Intercropping

This study examines how cassava/peanut intercropping affects rhizospheric soil physicochemical properties and microbial communities, finding improved nutrient content, pH, and microbial diversity.